Last word on point: counterpoint: exercise training does/does not induce vascular adaptations beyond the active muscle beds.
نویسندگان
چکیده
TO THE EDITOR: We thank the commentators (3) for taking the time to prepare their excellent submissions. We believe that the premise of the Point:Counterpoint concept is that protagonists adopt adversarial positions in order that the process of debate might stimulate some new insight or ideas. To paraphrase Oscar Wilde “A debate that is not dangerous is unworthy of being called a debate at all.” We hope that, with the help of the commentators who have all raised valid and thought-provoking issues, we may have achieved this goal. As highlighted by several of the commentators, further research should now ensue and we hope that exercise physiology evolves in new directions that focus attention on direct vascular adaptations and the authentic stimuli that are associated with exercise and physical (de)conditioning. It is our view that, to date, rather too much emphasis has been placed on the effects of exercise being secondary to changes in established cardiovascular risk factors (1). Since the discovery of prostaglandins, nitric oxide, endothelins, and other paracrine agents, it is now generally agreed that exercise has direct effects on the vasculature. We hope that the outcome of our Point:Counterpoint discussion (2, 4) is that further research will be stimulated to determine whether these effects are associated with patterns of shear stress, pressure oscillations, endothelial progenitor cell modulation, or other currently unidentified factors.
منابع مشابه
Point : Counterpoint “ Exercise training does / does not induce vascular adaptations beyond the active muscle beds ”
متن کامل
Comments on point: counterpoint: exercise training does/does not induce vascular adaptations beyond the active muscle beds.
TO THE EDITOR: Animal investigations permit invasive techniques and a spatial and temporal resolution not feasible in humans. Thus structural and functional adaptations to exercise training within the muscle resistance vasculature (i.e., arterioles) can be observed directly and related to blood flow within the same muscle (3–5). This approach is powerful because the hemodynamic response differs...
متن کاملComments on Point:Counterpoint: Exercise training does/does not induce vascular adaptations beyond the active muscle beds
TO THE EDITOR: Animal investigations permit invasive techniques and a spatial and temporal resolution not feasible in humans. Thus structural and functional adaptations to exercise training within the muscle resistance vasculature (i.e., arterioles) can be observed directly and related to blood flow within the same muscle (3–5). This approach is powerful because the hemodynamic response differs...
متن کاملVascular effects of exercise: endothelial adaptations beyond active muscle beds.
Endothelial adaptations to exercise training are not exclusively conferred within the active muscle beds. Herein, we summarize key studies that have evaluated the impact of chronic exercise on the endothelium of vasculatures perfusing nonworking skeletal muscle, brain, viscera, and skin, concluding with discussion of potential mechanisms driving these endothelial adaptations.
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ورودعنوان ژورنال:
- Journal of applied physiology
دوره 105 3 شماره
صفحات -
تاریخ انتشار 2008